What Is VDR?

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VDR is a gene which encodes a vitamin-D receptor protein. This protein regulates calcium absorption as well as bone growth. A variant of the gene, rs2228570 (FokI polymorphism) is associated with lower bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by the two components, and it is influenced by chromosomal location and binding preferences for certain hormones. Microarray studies of human cells indicate that more than 100 genes have an identifiable VDRE within their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository for data and documents pertinent to legal transactions, business or other proceedings that have restrictions on viewing and downloading. It uses a central server and an extranet connection that is an Internet connection with restricted access, to provide controlled access to users at specific times when users can browse the documents and data.

VDRs are typically used by investment banks and businesses involved in mergers and acquisitions. They need a secure platform to share information with potential buyers or investors in a clear and transparent manner and due diligence may require large amounts of data. Life science companies also utilize VDRs to keep everything from clinical trial results to HIPAA documentation.

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